ReCALL Software is useful for rapidly processing HIV genotype population based data from gene sequencers

ReCALL Software is useful for rapidly processing HIV genotype population based data from gene sequencers into aligned sequences, particularly convenient for laboratories doing routine HIV drug resistance or tropism testing.

FREE version by invitation only. Requires confirmation from Project Leader, Dr. Richard Harrigan.

ReCALL Software is useful for rapidly processing HIV genotype population based data from gene sequencers

ReCALL Software is useful for rapidly processing HIV genotype population based data from gene sequencers into aligned sequences, particularly convenient for laboratories doing routine HIV drug resistance or tropism testing.

Researchers at the University of British Columbia have developed cell lines expressing the glucose-dependent insulintropic

Researchers at the University of British Columbia have developed cell lines expressing the glucose-dependent insulintropic polypeptide (GIP) or glucagon-like peptide-1 (GLP-1) receptors, for diabetes and obesity research.  GIP is a gut hormone with obesity-promoting activities, and a promising drug target for obesity.  GLP-1 is a gut hormone with the ability to lower glucose levels, thus making it of great interest in developing diabetes therapies.  In the cell lines, the activation of the GLP-1 or GIP receptor leads to cAMP production and luciferase gene expression, enabling a bioassay of the activity of compounds targeting these receptors.

These cell lines are more sensitive than other available GIP or GLP-1 cell lines.  The GLP-1 receptor cell line can detect picomolar concentrations of activation compounds, such as GLP-1 peptides.  Moreover, the GLP-1 cell line is well suited to compound screening because it has been shown to also detect activity of modified GLP-1 peptides and small molecule compounds.

See Riedel et al., Am J Physiol Endocrinol, 2009.

Novel high molecular weight dendritic hyperbranched polyglycerol-aldehydes (HPG-ALD) are available for purchase. HPG-ALDs can be

Novel high molecular weight dendritic hyperbranched polyglycerol-aldehydes (HPG-ALD) are available for purchase. HPG-ALDs can be used for selective peptide separation for mass spectrometry based proteomic analysis.