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Nanoparticle-polymer complex for sustained release of oral care products


Project TitleNanoparticle-polymer complex for sustained release of oral care products
Track Codencli-015
Short Description

A process for preparation of nanoparticle-polymer multilayer complexes for sustained release of active oral agents, which can anchor and retain on the surface enamel of the teeth, for extended periods of activity.



Conventional layer-by-layer preparation scheme for preparing such nanoparticle-polymer multilayer complexes requires excessive use of polyanions and polycations with cumbersome separation process involved.


NCL scientists have developed a process for constructing nanoparticle-polymer complex for sustained release of active agents for oral care (for applications in toothpastes and oral rinses). Polymer multilayers are built up layer by layer on nanoparticles of 5-50 nm, consisting of a water repelling (hydrophobic) shell around a core of multiply (polyanion and polycation) charged material (the core can be of inorganics as silica, titania and/or clay) and encompassing outer layer with an affinity to the tooth enamel.


• The Indian market for oral care products grew to Rs. 3241crores at a growth rate of14.7% in 2009* and the market for US is headed to reach $8.9 billion by 2012# 
• There is a high market demand for novel, value added oral care products that will drive the market*,**

• The global toothpaste market is expected to reach $12.7 billion by 2012##
• The increase of sales is mainly seen due to growing awareness of hygiene and product innovation that provides additional features such as whitening and odor-fighting apart from just prevention of tooth decay

*, **, #, ##


• Precisely controlled polymer multilayers can be built on nanoparticles without the requirement of the cumbersome separation step after each coating of the polymer layers
• Active compounds localised as per the requirement by fine tuning the outer layer of the complexes- retained in the complex despite extensive rinsing with water
• Enables designing systems that can anchor and retain on the surface enamel of the teeth for extended periods by adjusting the ionic strengths


• Oral hygiene application- sustained release of antimicrobial/ flavour compounds


• Demonstrated at the lab scale/ proof-of-concept
• On the lookout for potential partners for spin-off and licensing
• Patent application filed: Indian #- 0696/DEL/2007


Case Manager: Magesh N
Phone: +91-20-25902982

Tagsnanoparticle, polymer, multilayer complex, sustained release, oral products, oral hygiene
Posted DateJan 2, 2012 5:21 AM


File Name Description
OralCareComplexes-Flyer None Download