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Nanoparticle-polymer complex for sustained release of oral care products

Details

Project TitleNanoparticle-polymer complex for sustained release of oral care products
Track Codencli-015
Websitehttp://nclinnovations.org/
Short Description


A process for preparation of nanoparticle-polymer multilayer complexes for sustained release of active oral agents, which can anchor and retain on the surface enamel of the teeth, for extended periods of activity.

Abstract


BACKGROUND

Conventional layer-by-layer preparation scheme for preparing such nanoparticle-polymer multilayer complexes requires excessive use of polyanions and polycations with cumbersome separation process involved.


TECHNOLOGY DESCRIPTION

NCL scientists have developed a process for constructing nanoparticle-polymer complex for sustained release of active agents for oral care (for applications in toothpastes and oral rinses). Polymer multilayers are built up layer by layer on nanoparticles of 5-50 nm, consisting of a water repelling (hydrophobic) shell around a core of multiply (polyanion and polycation) charged material (the core can be of inorganics as silica, titania and/or clay) and encompassing outer layer with an affinity to the tooth enamel.


MARKET POTENTIAL

• The Indian market for oral care products grew to Rs. 3241crores at a growth rate of14.7% in 2009* and the market for US is headed to reach $8.9 billion by 2012# 
• There is a high market demand for novel, value added oral care products that will drive the market*,**

• The global toothpaste market is expected to reach $12.7 billion by 2012##
• The increase of sales is mainly seen due to growing awareness of hygiene and product innovation that provides additional features such as whitening and odor-fighting apart from just prevention of tooth decay


*http://www.livemint.com/2009/05/06234303/HUL-losing-market-share-as-riv.html, **http://www.reuters.com/article/2011/05/11/idUS29974+11-May-2011+BW20110511, #http://www.packagedfacts.com/Oral-Care-Products-1190801/, ##http://www.prweb.com/releases/toothpaste_regular/whitening_tartar_control/prweb1537104.htm


VALUE/ADVANTAGES

• Precisely controlled polymer multilayers can be built on nanoparticles without the requirement of the cumbersome separation step after each coating of the polymer layers
• Active compounds localised as per the requirement by fine tuning the outer layer of the complexes- retained in the complex despite extensive rinsing with water
• Enables designing systems that can anchor and retain on the surface enamel of the teeth for extended periods by adjusting the ionic strengths


APPLICATIONS

• Oral hygiene application- sustained release of antimicrobial/ flavour compounds


TECHNOLOGY STATUS

• Demonstrated at the lab scale/ proof-of-concept
• On the lookout for potential partners for spin-off and licensing
• Patent application filed: Indian #- 0696/DEL/2007


CONTACT

Case Manager: Magesh N
Phone: +91-20-25902982
Email: m.nandagopal@ncl.res.in

 
Tagsnanoparticle, polymer, multilayer complex, sustained release, oral products, oral hygiene
 
Posted DateJan 2, 2012 5:21 AM

Files

File Name Description
OralCareComplexes-Flyer None Download