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Injectable biodegradable gels with hydrophobic pockets/cavity for delivery of drugs


Project TitleInjectable biodegradable gels with hydrophobic pockets/cavity for delivery of drugs
Track Codencli-018
Short Description

Injectable, biodegradable, polymer hydrogel (that cross links in-situ) with one or more hydrophobic cavities which can be used to deliver drugs, with the desired release profile - having various biomedical applications



Hydrogels are 3-D polymer networks with an unique ability to hold water, maintaining semi-solid state giving them physical characteristics similar to soft tissues. They need to be easily administrable as preformed hydrogels and exist as flowable aqueous solutions before injection and immediately turn in to standing gels upon administration


The hydrogel developed by NCL scientists can be in situ crosslinked (which makes it suitable for injectable systems), with one or more hydrophobic pocket(s) which can be used to deliver desired drugs with desired release profile (gelation time- 1 to 30 minutes; degradation time- 1- 30 days; storage modulus from 5-110 Kpas). It comprises of a polymer backbone, a hydrophobic pocket (moiety being triclosan) and a water soluble cross linker (paclitaxel solubilized in alpha tocopherol)


• The US market for advanced drug delivery has been projected to exceed $76 billion by 2014 -not many organizations exist which can fulfill the task of making such specialized delivery techniques on a large scale* Also significant market potential in wound care exists**



• Overcome the barrier of surgical implantation
• Does not require solvents as other biodegradable polymers might require which are harmful to the human body/some drugs may become inactive on coming in contact with the solvent
• In drug delivery applications, drugs can be loaded in the hydrophobic pockets present in the gels
• Provides precise control over the chain length, sequence and 3D arrangement of the polymer networks in the gels - hence prevents side reactions caused which may influence their performance


• In site specific drug delivery systems/depots
(Many important drugs are hydrophobic in nature and need to be administered in a solubilized form for the expected therapeutic effect- using our gel system, which has hydrophobic pockets to hold these drugs, the drugs can be delivered directly)
• Biomedicine- cell growing depots for tissue regeneration & protective membranes for the treatment of wounds
• Tissue engineering- space filling agents, delivery vehicles for bioactive molecules & tissue formation directing scaffolds


• Demonstrated at the lab scale
• Ready to be licensed
• Patent application filed: PCT #- IB2010/003190


Case Manager: Magesh N
Phone: +91-20-25902982

Tagsbiodegradable, polymer hydrogels, hydrophobic pockets, cavities, insitu crosslinked, injectable system, drug delivery, surgical implantation, polymer networks, 3D arrangement, tissue engineering
Posted DateJan 2, 2012 6:21 AM


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