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Tools for Vaccine and Drug Development for Cryptosporidium


Project TitleTools for Vaccine and Drug Development for Cryptosporidium
Track Code2072-Organism
Short Description


  • Basic research, including the development of forward and reverse genetic tools

  • Vaccine and drug development for Cryptosporidium infection in both humans and livestock

  • Platform system for introduction of additional antigens for protection against additional diseases

Problems Addressed

  • May allow establishment of an animal model of disease

  • Provides a means to develop currently non-existent genetic tools for further research

  • Supports development of a first vaccine against Cryptosporidium



Cryptosporidium is a genus of protozoans that can cause gastrointestinal illness with diarrhea in humans and animals.  Cryptosporidium parvum organisms are most often spread through water (both drinking water and recreational water) and this type of infection is the second most common cause of diarrheal disease in infants. 

Researchers at the University of Georgia have developed an innovative methodology for transfecting Cryptosporidium organisms.  The transfectants can then be used to establish reporter pathogens for such applications as measuring infection, pathogenesis, and efficacy of therapeutic treatments.  The transfected Cryptosporidium could also then be used for drug screening and vaccine development.   


Published PCT WO2015017767

Tagscryptosporidium, vaccine, disease
Posted DateNov 14, 2017 3:44 PM


Rachael Widener


File Name Description
Striepen 2072 Organism.docx None Download