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Antibody to Tau Nitrated at Tyrosine 18

Details

Project TitleAntibody to Tau Nitrated at Tyrosine 18
Track Code2007-167
Short Description

Tau-nY18 is a mouse monoclonal antibody (mAb) specific for human tau wherein the Tyrosine residue at position 18 has been nitrated.

Abstract

The antibody is of the IgG1 subtype and is both specific to human tau and nitration at Tyr18.  The Tau-nY18 mAb can detect human tau with a nitro group attached at amino acid Tyr18. The nitration of Tyr 18 slows and prevents the formation of human tau filaments.  Nitration of Tyr18 plays a role in astrocyte activation, an early event associated with amyloid plaque formation. Therefore, this antibody is useful in studying the role of nitration of tau and the progression of Alzheimer’s disease.

The Tau-nY18 mAb was derived from a hybridoma cell line created through the fusion of SP2/o myeloma cells with splenocytes from a mouse immunized with a synthetic peptide corresponding to human tau amino acids 12-24 that was nitrated at Tyr18.  Tau-nY18 is specific for human tau constructs nitrated at Tyr18.

 
Tagshealthcare, neurology, antibodies, research tools, diagnostic tools
 
Posted DateMar 18, 2011 3:36 PM

Inventor(s)

Lester Binder 

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Status

This antibody is available to be licensed as a research reagent.

Further information regarding this antibody is available in the following reference: A possible link between astrocyte activation and tau nitration in Alzheimer's disease. Reyes, et al. Neurobiology of Disease. 2008. 31(2):198-208

Contact Information

Gwendolyn Humphreys, PhD

Invention Associate

(p) 847-467-0308
(e) Gwendolyn.Humphreys@northwestern.edu